%PDF-1.7
%
48 0 obj
<>
endobj
45 0 obj
<>stream
Acrobat Distiller 5.0 (Windows)
2013-03-18T04:53:24Z
2018-05-07T07:01:24-07:00
2018-05-07T07:01:24-07:00
3B2 Total Publishing System 8.07e/W Unicode
application/pdf
1398 1412..1415
uuid:1633788c-1dd2-11b2-0a00-7d0927bdd100
uuid:1633788f-1dd2-11b2-0a00-1e0000000000
endstream
endobj
46 0 obj
<>
endobj
49 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 33 0 R/Type/Page>>
endobj
1 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Thumb 35 0 R/Type/Page>>
endobj
5 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Thumb 37 0 R/Type/Page>>
endobj
10 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Thumb 39 0 R/Type/Page>>
endobj
108 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
122 0 obj
[128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R]
endobj
123 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 622 Tm
(DNA Gridiron Nanostructures Based on Four-Arm Junctions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 609 Tm
(Dongran Han, Suchetan Pal, Yang Yang, Shuoxing Jiang, Jeanette Nangreave\
, Yan Liu and Hao Yan)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 562.99997 Tm
(DOI: 10.1126/science.1232252)Tj
5.50301 1 Td
( \(6126\), 1412-1415.)Tj
/T1_0 1 Tf
-1.668 0 Td
(339)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 92 490.99985 Tm
(created, including highly curved structures, such as a sphere and a scre\
w.)Tj
0 1 TD
(four-arm junctions link together to form a two-layer square frame. A var\
iety of two- and three-dimensional structures were )Tj
11.61497 1.00001 Td
( \(p. 1412\) now describe a more flexible approach based on a ''gridiron\
unit'' in which four)Tj
/T1_3 1 Tf
-2.27899 0 Td
(et al.)Tj
/T1_0 1 Tf
-2.16699 0 Td
(Han )Tj
/T1_1 1 Tf
-7.16899 0 Td
(parallel helices. )Tj
T*
(strands. In these DNA origami structures, the path of the scaffold has b\
een restricted by a double-crossover motif to form )Tj
3.125 1.00001 Td
(Complex DNA nanostructures can be formed from a long scaffold strand of \
DNA by binding many shorter ''staple'')Tj
/T1_0 1 Tf
-3.125 1 Td
(Rewiring DNA Origami)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 425 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 423 Tm
(http://science.sciencemag.org/content/339/6126/1412)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 382.99997 Tm
(MATERIALS)Tj
0 1.00001 TD
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 387 Tm
(http://science.sciencemag.org/content/suppl/2013/03/20/339.6126.1412.DC1\
)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 347 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 336.99997 Tm
(http://science.sciencemag.org/content/339/6126/1412#BIBL)Tj
0 g
0 1 TD
(This article cites 9 articles, 3 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 311 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 309 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
522 114 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
8 0 0 8 100.45605 77.99991 Tm
( is a registered trademark of AAAS.)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
T*
(licensee American Association for the Advancement of Science. No claim t\
o original U.S. Government Works. The title )Tj
0 1.00001 TD
(Science, 1200 New York Avenue NW, Washington, DC 20005. 2017 \251 The Au\
thors, some rights reserved; exclusive )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_1 1 Tf
0 -8 8 0 576 317.9801 Tm
(on May 7, 2018)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
127 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(